Usual Dose & Administration
Usual Adult Dose
600 mg IV q8h
Adjustment of Dose & Administration
Indication-Specific Adjustment
| Indication | Usual Dose |
| Cellulitis | 600 mg IV q8h |
| Necrotizing fasciitis | 900 mg IV q8h |
| Pneumocystis jiroveci pneumonia | 900 mg IV q8h or 600 mg IV q6h |
| CNS toxoplasmosis | 600 mg IV q6h |
| Other CNS infection | 900 mg IV q8h |
| Surgical prophylaxis | 900 mg IV x 1 pre-op |
Renal Adjustment
No renal adjustment necessary
Drug-Specific Information
Except for CNS toxo and PCP with sufa allergy (600 mg q6h), other CNS infections (600 mg q6h), and necrotizing fasciitis (900 mg q8h), doses of 600 mg q6h, 900 mg q6h and 900 mg q8h will result in automatic switch to 600 mg q8h per P&T-approved protocol
IV to PO Conversion:
600 mg IV q8h = 450 mg PO q8h OR 300 mg PO q6h
Bioavailability: 90%
Cost Index
$ (1-10)
General Notes
- Up to date cost information for select antimicrobials is found in the PDF on this page. https://www.customid.org/antimicrobial/antimicrobial-cost-chart
- Information about how to administer select IV antimicrobials outpatient (OPAT) is found here https://assets.customid.org/OPATchart%20Final.pdf
- When dosing guidance is provided it is important to note the following:
Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.