Criteria & Principles
- Ampicillin/sulbactam lacks activity against Pseudomonas, MRSA, and AmpC GNRs
- Sulbactam is the active component against Acinetobacter spp. but only comes in combination with ampicillin
Usual Dose & Administration
Usual Adult Dose
1.5-3 g IV q6h
Adjustment of Dose & Administration
Indication-Specific Adjustment
| Indication | CrCl (mL/min) | |||
| >30 | 15-29 | <15, IHD | CRRT | |
|
Infections caused by: Acinetobacter spp (note: sulbactam is the active component) Usually dose is >/= to 6 grams/d sulbactam |
3g q4h-6h | 3g q6h |
3g q8h |
3g q6h |
|
Severe infections including: Diabetic foot ulcers Lower respiratory tract infections Endocarditis (HACEK organisms, Enterococcus) Osteomyelitis Orbital cellulitis |
3g q6h | 3g q12h |
3g q24h (give dose after dialysis on dialysis days) |
3g q8-12h |
|
Acute bacterial sinusitis Community-acquired aspiration pneumonia Cellulitis (non-purulent) UTI (complicated) |
1.5g q6h | 1.5g q12h |
1.5g q24h (give dose after dialysis on dialysis days) |
1.5g q8-12h |
Cost Index
$ (1-10)
General Notes
- Up to date cost information for select antimicrobials is found in the PDF on this page. https://www.customid.org/antimicrobial/antimicrobial-cost-chart
- Information about how to administer select IV antimicrobials outpatient (OPAT) is found here https://assets.customid.org/OPATchart%20Final.pdf
- When dosing guidance is provided it is important to note the following:
Fixed (ie non weight-based) doses in adults are historically based on a 70 kg patient. Specific disease states or individual patients may warrant dosages that differ from the above recommendations. Since product-specific criteria for dose adjustment based on creatinine clearance exist, consult product information regarding specific recommendations for dosage adjustment based on estimated creatinine clearance.